I don't know about in-car audio, only as a bass player in a band, but I wouldn't go with open backs if you want low end - all sorts of vibrations and resonant frequency problems in the surrounding area can make the sound unpleasant. A sealed cabinet was my preference as it punched out the low fundamentals, but it heavily restricts the sucking in of air as the cone moves, so your amp has to work harder. That wasn't a problem with my bass amplifier but a ported design, as z22se suggests, is a good compromise for focused bass and bigger sound pressure level (SPL) for your Watts.
I'm a bass player and I can tell (and have a preference) between sealed and ported cabs, but then I prefer EL34 valves to 6550s (and particular brands of EL34), Elites stainless steel strings to Rotosound nickels etc etc. Important to me, but even the guitarist - never mind the audience - never noticed any difference. A ported woofer will probably suit you best. In a tight space like a car, multiple speakers arranged vertically sound punchier than horizontally but, again, not significantly to most people. One thing that I hope you do know: your amplifier will have a range of impedances (or a selector) that it can work with. Adding more speakers, and serial or parallel wiring, will significantly change the overall impedance and you need to make sure you don't cause damage to the amplifier.